Genmab and GSK announce amendment to ofatumumab agreement
The two companies have announced an amendment to the ofatumumab co-development and commercialization agreement. In the agreement, GlaxoSmithKline (GSK) will take responsibility for developing ofatumumab in autoimmune indications whilst continuing to jointly develop ofatumumab with Genmab in oncology indications.
Genmab will receive an upfront payment of GBP 90 million (DKK 815 million) from GSK. Genmab’s future funding commitment for the development of ofatumumab in oncology indications will be capped at a total of GBP 145 million (DKK 1,314 million), including a yearly spending cap of GBP 17 million (DKK 154 million) for each of the next six years starting with 2010. Future milestones due to
Genmab under the oncology development programme will be reduced by 50%. There will be no change in royalty tiers to Genmab in the oncology program.
GSK is currently planning a number of Phase II clinical studies to take ofatumumab forward in autoimmune indications. GSK will be solely responsible for funding the development in these indications. As a result, Genmab will forego development milestones for autoimmune indications and the first two sales milestones while retaining a double digit royalty on sales.
“The amendment to the ofatumumab agreement clearly highlights Genmab and GSK’s commitment to further develop this important product,” said Prof. Jan G.J. van de Winkel, Ph.D., Chief Executive Officer of Genmab. “We have a really excellent partner in GSK. Their flexibility has allowed us to not only ensure that we extract the best possible value from ofatumumab, but also strengthen the financial security of Genmab.”
